The Titans have had their way with the Bills the past few seasons. Despite the successes Buffalo has had, Tennessee have just been a problem.
In total, 95 percent of those polled went with Buffalo. [10-point favorite](https://sportsbookwire.usatoday.com/2022/09/18/tennessee-titans-at-buffalo-bills-odds-picks-and-predictions/) in most sportsbooks, including [Tipico](https://media.tipico.com/C.ashx?btag=a_94b_322c_tennessee-titans-at-buffalo-bills-odds-picks-and-predictions-pos2&affid=47&siteid=94&adid=322&c=tennessee-titans-at-buffalo-bills-odds-picks-and-predictions-pos2). Despite the successes Buffalo has had, Tennessee have just been a problem.
Henry has been a force in the four games he's played against the Bills. Here's how he's found so much success against them.
In his four games against the Bills, he has averaged 6.3 yards per carry on rushes up the middle, Against the Bills on Monday, Henry will likely be used in just about every situation. The Bills should also expect to see plenty of Henry early on drives. But if there's one thing Henry has shown in the past against the Bills, it's that he's certain to be ready for the challenge. He scored three times on the ground as the Titans edged out a narrow 34-31 victory on "Monday Night Football" in Week 6. Against the Bills, he rushed off the edge only five times, and instead opted to rush behind left guard Rodger Saffold and center Ben Jones seven times, Through the first three games of Henry's career against the Bills, he saw only modest results. He also scored three touchdowns, twice in the 2020 matchup against Buffalo and once in 2019. Stopping Henry is always easier said than done, but there are some trends that at least point to how he has found success against Buffalo in the past. He has only taken handoffs on third down four times against the Bills, while the rest of his carries have come on first or second down. When Derrick Henry gets going, there are few teams in the NFL that can stop him. But in 2021, he turned it up a notch.
See odds, TV information and expert predictions for the Bills vs. Titans Monday Night Football game.
Titans](https://theathletic.com/3602937/2022/09/18/bills-thoughts-vs-titans/) [How Bills’ A.J. Brown](https://theathletic.com/nfl/player/aj-brown-EJI9GRcayoZKGPpF/), who had a monster opening week game for the [Philadelphia Eagles](https://theathletic.com/nfl/team/eagles/)), and still have [Ryan Tannehill](https://theathletic.com/nfl/player/ryan-tannehill-XUAZZ3AjcOywkoZU/) at quarterback. Epenesa conquered weight roller coaster in hopes of breakout 2022](https://theathletic.com/3600859/2022/09/17/bills-aj-epenesa/) Buffalo’s defense tormented [Matthew Stafford](https://theathletic.com/nfl/player/matthew-stafford-H0tJFcdflWXgxumn/), sacking him and intercepting him. [Josh Allen](https://theathletic.com/nfl/player/josh-allen-9zLTUSPpy6pFa4xs/) didn’t play his best game. It was one of the most impressive showings of the [NFL](https://theathletic.com/nfl/)’s opening week and helped confirm that they are one of the league’s elite teams and should be at the top of every Super Bowl contender list.
Each Monday, we'll finish off the week that was in the NFL with a look at value spots in the remaining game - or in this case, games - under one condition: ...
[McKenzie](https://www.thescore.com/nfl/players/83449) would likely be next in line for a bump in overall snaps if [Gabe Davis](https://www.thescore.com/nfl/players/115240) is unable to go. [Ryan Tannehill](https://www.thescore.com/nfl/players/21390) will likely be asked to keep up with [Josh Allen](https://www.thescore.com/nfl/players/94699) - who turned out to be the player some scouts hoped Tannehill would be when he entered the league as a big, fast, athletic project. Henry's still a theoretical threat and will be the focus of the Bills' run defense. If you were looking for some added risk and a two-to-one payout while still buying a piece of the Bills' high-powered offense, this is safer than getting dropped through a folding table. Matt Russell is a betting writer for theScore. He might record a run longer than 17.5 yards, but the game script may force the Titans into being pass-heavy, so fading Henry is the play Monday. The Bills have already seen that type of smoke and will be ready for it - especially after getting upset in Nashville last year. Each Monday, we'll finish off the week that was in the NFL with a look at value spots in the remaining game - or in this case, games - under one condition: you promise not to chase. Meanwhile, the Titans have replaced The last time he showed his trademark downhill explosiveness was a 76-yard run in last season's meeting with the Bills. Brown](https://www.thescore.com/nfl/players/111194) with [Robert Woods](https://www.thescore.com/nfl/players/43919) (receiving yards total: 40.5) and [Treylon Burks](https://www.thescore.com/nfl/players/173990) (receiving yards total: 27.5), and they might not have much in the way of a top-end gear as a team. A hostile environment awaits the [Titans](https://www.thescore.com/nfl/teams/14), who appear to be reeling from their finish to last season.
The Buffalo Bills will face off against the Tennessee Titans on Monday Night Football as part of a doubleheader to close out Week 2 of the 2022 NFL season.
The decline of Henry’s effectiveness, like most things, is a result of multiple factors all simultaneously at play. He may have run for fewer yards (1985 vs the 2067 in 2020), but his yards after contact was higher in 2019 than in 2020 (4.16 vs 3.85), and his breakaway run percentage (which represents the percentage of a player’s yards that come on runs that go for over 15 yards) was a career-high 33.5. In the two years prior with Arthur Smith calling the plays, the Titans ran 556 zone runs with Henry compared to 220 gap runs (about a 72% zone run rate). In the time Downing has called plays, the Titans have run 144 zone runs with Henry compared to 116 gap runs (about 55% zone runs). In Week 1 against the In 2021 it was 69%. In 2020, it was 2.5. In Week 1 of 2022, it was 67.0. This is reflected in the yards-after-contact numbers dropping as mentioned above. [Buffalo Bills](https://www.buffalorumblings.com/) will face off against the Tennessee Titans on Monday Night Football as part of a doubleheader to close out Week 2 of the 2022 NFL season. Last season (2021) represented a notable step back in efficiency from 2020, with his yards per attempt dropping from 5.2 to 4.2, his yards after contact per attempt continuing its descent from its peak of 4.21 in 2018 all the way down to 3.28, and his breakaway percentage continuing its decline to 26.4%. But those hits take their toll on everyone, even a player of Henry’s caliber.
The Tennessee Titans could not ask for a more difficult Week 2 game than a trip to the Buffalo Bills.
The Bills are the No. Beating the Bills is a tough ask, especially for a team that could not beat the New York Giants. The Bills appear to be one of the best teams in the AFC. The Titans didn’t answer any questions in their opener. Yes, this is the kind of spot the Titans have thrived in with Mike Vrabel as coach. The Titans have a knack for rising to the occasion in primetime games (they’re 8-2 on Monday Night Football) and responding well from bad loses under coach Mike Vrabel.
Breaking down the DFS strategies and approaches to playing the DraftKings Showdown slate for the Tennessee Titans-Buffalo Bills Monday Night Football ...
Then, we see where the leverage may exist. Here are the 500 CPT choices from those matchups by position rank according to salary. The most unique part of the format, and therefore the biggest opportunity for a competitive advantage, is choosing your CPT. Roster Position Position All the players aren’t perfect matches, but that’s why we use 100 similar matchups and not just the single most similar. TE WR RB SEA QB [Seattle Seahawks](https://www.pff.com/nfl/teams/seattle-seahawks/29)– [St.
Despite Tua's big day, the Bills are favored in the Dolphins' stadium.
In 2020, Ryan Fitzpatrick threw a TD pass with 49 seconds left to close the gap from 11 points to 3 but the onside kick was unsuccessful. Buffalo is favored by 4.5 points over the 2-0 Dolphins, who stormed back with a furious fourth quarter after laying an egg for 45 minutes on Sunday. [Buffalo Bills](https://www.buffalorumblings.com/) haven’t even played their Week 2 game on Monday night, but [ DraftKings Sportsbook already has them as a rather large road favorite for their Week 3 game](https://dksb.sng.link/As9kz/30m1?_dl=https%3A%2F%2Fsportsbook.draftkings.com%2Fgateway%3Fs%3D671872939%26wpcid%3D163148%26wpcn%3DOpeningOdds%26wpsrc%3DVox%26wpcrid%3DOdds&pcid=163148&pscn=Odds&pcrn=OpeningOdds&psn=Vox) against the [Miami Dolphins](https://www.thephinsider.com/).
The best bets for Tennessee and Buffalo's rematch in primetime.
[Treylon Burks](/nfl/players/3122944/treylon-burks/) receiving yards: Over 26.5 (+100). [Ryan Tannehill](/nfl/players/1273654/ryan-tannehill/) props [Ryan Tannehill](/nfl/players/1273654/ryan-tannehill/) [View Profile](/nfl/players/1273654/ryan-tannehill/) [Tyler Bass](/nfl/players/2188356/tyler-bass/) made extra points: Over 2.5 (-169). [Stefon Diggs](/nfl/players/2000038/stefon-diggs/) longest reception: Over 23.5 (-117). I love the Over on passing yards here. I do not see any value on Allen's interception number, but the Over on rushing yards is intriguing. Brown](/nfl/players/2258303/a-j-brown/) and are coming off of a tough upset loss to the [New York Giants](https://www.cbssports.com/nfl/teams/NYG/new-york-giants/) in Week 1. They can lose to the [New York Jets](https://www.cbssports.com/nfl/teams/NYJ/new-york-jets/) one week, and then blow out the eventual Super Bowl champions on the road, just like they did last season. Tannehill Over 1.5 passing touchdowns at plus money looks intriguing, but you have to remember he threw two or more touchdowns in just four games last year. The pick: Over 47.5. This is a rematch of an incredible Monday night game that took place last year, when Henry ran for 143 yards and three touchdowns, while [Jeffery Simmons](/nfl/players/2248637/jeffery-simmons/) stuffed [Josh Allen](/nfl/players/2181054/josh-allen/) at the goal line on fourth down with just 22 seconds remaining in the fourth quarter. the
Tennessee defensive tackle Jeffery Simmons practiced regularly against left guard Rodger Saffold since the Titans drafted him in 2019.
“We’re going to go out there and just play football, do what we do and and try to execute. Titans quarterback Ryan Tannehill had a natural switch going from seeing the Bills regularly in the AFC East while playing for Miami. The Titans routed Buffalo in 2020 in a rare Tuesday night game postponed after Tennessee became the first NFL team with a COVID-19 outbreak during the first season of the pandemic. Both the Bills and Titans have had roster turnover since last season. Allen has played Tennessee every season he's been in the NFL and sees the familiarity with the Titans helping a bit. “Obviously, a big one for them, too,” Hyde said. So, we got to be ready for whatever punch they throw out our way and try to put our best foot forward.” And we’re always going to be looking out for each other once the final whistle blows.” Monday night is the home opener for Buffalo. He started his career with the Los Angeles Rams and won in Los Angeles last season with the Titans. This isn't the first time Saffold has had to face off against former teammates. For me, I'm going to say I play way harder than I practice.”
SportsLine simulated Tennessee Titans vs. Buffalo Bills during the Monday Night Football doubleheader 10000 times.
Titans](https://www.sportsline.com/nfl/game-forecast/NFL_20220919_TEN@BUF/) and just locked in its picks and NFL predictions. [Stefon Diggs](/nfl/players/2000038/stefon-diggs/) is a true No. [Visit SportsLine now to see which side of the Titans vs. [Gabe Davis](/nfl/players/2804813/gabe-davis/) (questionable, ankle) will steps into a larger role as the No. Brown](/nfl/players/2258303/a-j-brown/) to the [Philadelphia Eagles](https://www.cbssports.com/nfl/teams/PHI/philadelphia-eagles/) this offseason. Now, here are several [NFL odds](https://www.sportsline.com/nfl/odds/) and betting lines for Titans vs. [You can head to SportsLine now to see the model's picks](https://www.sportsline.com/insiders/titans-vs-bills-nfl-lines-odds-picks-proven-nfl-model-reveals-predictions-for-a-monday-night-football-matchup/#ttag=09172022_agg_cbssports_picks_football_nfl_model_titansbillsMNFmodel). [Tennessee Titans](https://www.cbssports.com/nfl/teams/TEN/tennessee-titans/) (0-1) visiting the [Buffalo Bills](https://www.cbssports.com/nfl/teams/BUF/buffalo-bills/) (1-0) in the first half of a Monday Night Football doubleheader. SportsLine's model is leaning Over on the total, with the teams projected to combine for 51 points. Davis gashed the [Rams](https://www.cbssports.com/nfl/teams/LAR/los-angeles-rams/)' defense for several big plays last week. The model enters Week 2 of the 2022 NFL season on an incredible 139-98 run on top-rated [NFL picks](/nfl/picks/experts) that dates back to the 2017 season. Buffalo is favored by 10 points in the latest Bills vs.
Larry Harstein has locked in Buffalo Bills vs. Tennessee Titans expert picks for Monday Night Football.
Bills](https://www.sportsline.com/nfl/game-forecast/NFL_20220919_TEN@BUF/) and locked in his [NFL picks](/nfl/picks/experts) and predictions. [Josh Allen](/nfl/players/2181054/josh-allen/) completed 26 of 31 attempts (83.9%) for 297 yards and three touchdowns against the Rams last week. [Tennessee Titans](https://www.cbssports.com/nfl/teams/TEN/tennessee-titans/) take on the [Buffalo Bills](https://www.cbssports.com/nfl/teams/BUF/buffalo-bills/). Henry has 75 or more yards from scrimmage in 12 of his past 1 games, and rushed for 143 yards and three touchdowns in the last meeting against Buffalo. [Visit SportsLine now to see which side of the Bills vs. Here are several [NFL odds](https://www.sportsline.com/nfl/odds) and trends for Bills vs. He led the Bills with eight catches for 122 yards and one touchdown in last week's victory over Los Angeles. In the last meeting against the Titans, Allen passed for 353 yards and three touchdowns with an interception for a 107.8 rating. You can [head to SportsLine to see his picks](https://www.sportsline.com/insiders/titans-vs-bills-game-line-odds-nfl-expert-releases-pick-for-monday-night-football-showdown/#ttag=09172022_agg_cbssports_picks_football_nfl_larryhatstein_titansbillsMNFexpert). Buffalo is a 10-point favorite in the latest Titans vs. Hartstein went 68-50 ATS (58 percent) and 8-3 on money-line plays last season for a profit of $1,552. The Bills (1-0), who won the AFC East at 11-6 in 2021, crushed the defending [Super Bowl](/nfl/superbowl/) champion [Los Angeles Rams](https://www.cbssports.com/nfl/teams/LAR/los-angeles-rams/) 31-10 on the road.
Henry has been a force in the four games he's played against the Bills. Here's how he's found so much success against them.
In his four games against the Bills, he has averaged 6.3 yards per carry on rushes up the middle, Against the Bills on Monday, Henry will likely be used in just about every situation. The Bills should also expect to see plenty of Henry early on drives. But if there's one thing Henry has shown in the past against the Bills, it's that he's certain to be ready for the challenge. He scored three times on the ground as the Titans edged out a narrow 34-31 victory on "Monday Night Football" in Week 6. Against the Bills, he rushed off the edge only five times, and instead opted to rush behind left guard Rodger Saffold and center Ben Jones seven times, Through the first three games of Henry's career against the Bills, he saw only modest results. He also scored three touchdowns, twice in the 2020 matchup against Buffalo and once in 2019. Stopping Henry is always easier said than done, but there are some trends that at least point to how he has found success against Buffalo in the past. He has only taken handoffs on third down four times against the Bills, while the rest of his carries have come on first or second down. When Derrick Henry gets going, there are few teams in the NFL that can stop him. But in 2021, he turned it up a notch.
NFL fans got used to the Week 1 doubleheader for "Monday Night Football." That doubleheader was scrapped, but brought back for Week 2 this season.
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The Buffalo Bills host the Tennessee Titans in Orchard Park Monday Night as both teams usher in Week 2 of their respective schedules.
Hungry for more Buffalo Bills news? Are you a member of Bills Mafia? [HERE](https://www.si.com/nfl/bills/news) Despite his quiet 82 rushing yards in the Titans' Week 1 loss to the Giants, Buffalo has to expect the running game to be a focus for Tennessee. 1 against the pass. The Bills face a motivated Tennessee Titans team on Monday night from Highmark Stadium. the Titans.](https://sportsbook.fanduel.com/navigation/nfl) [Ken Dorsey's first game as Buffalo's offensive coordinator](https://www.si.com/nfl/bills/news/buffalo-ken-dorsey-coach-los-angeles-la-rams-josh-allen-heckuva-game-stefon-diggs): That’s a recipe for success.” “I think Coach Dorsey called a heckuva game,” Allen said. Wide receiver Gabe Davis sustained an ankle injury at week’s end, and he’s officially listed as questionable for the game. [SI SportsBook](https://www.sisportsbook.com/football/usa/nfl/tennessee-titans-buffalo-bills-e-438393/)